| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
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| Ligand | BDBM50201230 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453858 (CHEMBL885860) |
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| IC50 | 130±n/a nM |
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| Citation |  Boschelli, DH; Barrios Sosa, AC; Golas, JM; Boschelli, F Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of SKS-927. Bioorg Med Chem Lett17:1358-61 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase Src |
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| Name: | Proto-oncogene tyrosine-protein kinase Src |
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| Synonyms: | Proto-oncogene c-Src | SRC_RAT | Src | Tyrosine-protein kinase SRC | p60-Src | pp60c-src |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59976.76 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_453858 |
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| Residue: | 536 |
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| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGAFPASQTPSKPASADGHRGPNAAFVPPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKY
LRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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| BDBM50201230 |
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| n/a |
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| Name | BDBM50201230 |
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| Synonyms: | 4-(2,4-dichloro-5-methoxyphenylamino)-6-ethoxy-7-(4-(4-methylpiperazin-1-yl)but-1-ynyl)quinoline-3-carbonitrile | CHEMBL240830 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29Cl2N5O2 |
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| Mol. Mass. | 538.468 |
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| SMILES | CCOc1cc2c(Nc3cc(OC)c(Cl)cc3Cl)c(cnc2cc1C#CCCN1CCN(C)CC1)C#N |
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| Structure | 
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