| Reaction Details |
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 | Report a problem with these data |
| Target | von Hippel-Lindau disease tumor suppressor |
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| Ligand | BDBM50615684 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2303790 |
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| IC50 | 164±n/a nM |
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| Citation |  Han, X; Wang, C; Qin, C; Xiang, W; Fernandez-Salas, E; Yang, CY; Wang, M; Zhao, L; Xu, T; Chinnaswamy, K; Delproposto, J; Stuckey, J; Wang, S Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem62:941-964 (2019) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| von Hippel-Lindau disease tumor suppressor |
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| Name: | von Hippel-Lindau disease tumor suppressor |
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| Synonyms: | Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL |
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| Type: | Protein |
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| Mol. Mass.: | 24136.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P40337 |
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| Residue: | 213 |
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| Sequence: | MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPR
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFR
DAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDI
VRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
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| BDBM50615684 |
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| n/a |
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| Name | BDBM50615684 |
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| Synonyms: | CHEMBL4565531 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34N4O4S |
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| Mol. Mass. | 486.627 |
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| SMILES | C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(C)=O)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r| |
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| Structure | 
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