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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Chk1 | ||
| Ligand | BDBM50204724 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_442099 (CHEMBL891237) | ||
| IC50 | 1473±n/a nM | ||
| Citation |  Tong, Y; Claiborne, A; Stewart, KD; Park, C; Kovar, P; Chen, Z; Credo, RB; Gu, WZ; Gwaltney, SL; Judge, RA; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Chk1 | |||
| Name: | Serine/threonine-protein kinase Chk1 | ||
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 54443.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_166295192 | ||
| Residue: | 476 | ||
| Sequence: |
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| BDBM50204724 | |||
| n/a | |||
| Name | BDBM50204724 | ||
| Synonyms: | (1r,4r)-4-methyl-N-((3-phenyl-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl)cyclohexanamine | CHEMBL428398 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27N3 | ||
| Mol. Mass. | 357.4913 | ||
| SMILES | C[C@H]1CC[C@@H](CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccccc2)c1 |wU:4.7,wD:1.0,(-8.47,-11.13,;-7.14,-10.37,;-5.81,-11.14,;-4.47,-10.38,;-4.46,-8.84,;-5.8,-8.07,;-7.13,-8.83,;-3.13,-8.08,;-1.8,-8.85,;-.46,-8.08,;-.46,-6.53,;.87,-5.76,;2.2,-6.53,;2.2,-8.08,;3.67,-8.56,;4.59,-7.31,;6.07,-6.83,;6.07,-5.27,;4.59,-4.79,;3.67,-6.05,;7.31,-7.73,;7.14,-9.26,;8.39,-10.17,;9.79,-9.54,;9.95,-8,;8.71,-7.11,;.87,-8.85,)| | ||
| Structure | 
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