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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Chk1 | ||
| Ligand | BDBM50204716 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_442099 (CHEMBL891237) | ||
| IC50 | 535±n/a nM | ||
| Citation |  Tong, Y; Claiborne, A; Stewart, KD; Park, C; Kovar, P; Chen, Z; Credo, RB; Gu, WZ; Gwaltney, SL; Judge, RA; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Chk1 | |||
| Name: | Serine/threonine-protein kinase Chk1 | ||
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 54443.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_166295192 | ||
| Residue: | 476 | ||
| Sequence: |
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| BDBM50204716 | |||
| n/a | |||
| Name | BDBM50204716 | ||
| Synonyms: | 4-(6-(((1r,4r)-4-methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzenesulfonamide | CHEMBL243398 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H28N4O2S | ||
| Mol. Mass. | 436.57 | ||
| SMILES | C[C@H]1CC[C@@H](CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)S(N)(=O)=O)c1 |wU:4.7,wD:1.0,(-9.56,-2.9,;-8.22,-2.14,;-6.89,-2.91,;-5.55,-2.14,;-5.54,-.62,;-6.89,.16,;-8.21,-.6,;-4.22,.15,;-2.88,-.62,;-1.55,.15,;-1.55,1.7,;-.22,2.47,;1.11,1.71,;1.11,.15,;2.58,-.32,;3.5,.92,;4.98,1.4,;4.98,2.95,;3.5,3.44,;2.58,2.18,;6.22,.5,;6.06,-1.04,;7.3,-1.94,;8.7,-1.31,;8.86,.22,;7.62,1.12,;9.95,-2.22,;11.19,-3.12,;9.05,-3.47,;10.85,-.98,;-.22,-.62,)| | ||
| Structure | 
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