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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Chk1 | ||
| Ligand | BDBM50204711 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_442099 (CHEMBL891237) | ||
| IC50 | 124±n/a nM | ||
| Citation |  Tong, Y; Claiborne, A; Stewart, KD; Park, C; Kovar, P; Chen, Z; Credo, RB; Gu, WZ; Gwaltney, SL; Judge, RA; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Chk1 | |||
| Name: | Serine/threonine-protein kinase Chk1 | ||
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 54443.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_166295192 | ||
| Residue: | 476 | ||
| Sequence: |
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| BDBM50204711 | |||
| n/a | |||
| Name | BDBM50204711 | ||
| Synonyms: | 4-(6-(((1r,4r)-4-methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenol | CHEMBL242736 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27N3O | ||
| Mol. Mass. | 373.4907 | ||
| SMILES | C[C@H]1CC[C@@H](CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(O)cc2)c1 |wU:4.7,wD:1.0,(-9.65,-1.94,;-8.31,-1.18,;-6.98,-1.95,;-5.64,-1.18,;-5.64,.35,;-6.97,1.13,;-8.3,.36,;-4.3,1.12,;-2.97,.35,;-1.64,1.11,;-1.63,2.66,;-.31,3.43,;1.03,2.66,;1.03,1.11,;2.5,.64,;3.42,1.88,;4.9,2.36,;4.9,3.92,;3.42,4.4,;2.5,3.14,;6.14,1.46,;5.97,-.07,;7.21,-.98,;8.62,-.35,;9.87,-1.26,;8.78,1.19,;7.54,2.09,;-.3,.34,)| | ||
| Structure | 
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