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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Chk1 | ||
| Ligand | BDBM50204718 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_442099 (CHEMBL891237) | ||
| IC50 | 966±n/a nM | ||
| Citation |  Tong, Y; Claiborne, A; Stewart, KD; Park, C; Kovar, P; Chen, Z; Credo, RB; Gu, WZ; Gwaltney, SL; Judge, RA; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Chk1 | |||
| Name: | Serine/threonine-protein kinase Chk1 | ||
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 54443.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_166295192 | ||
| Residue: | 476 | ||
| Sequence: |
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| BDBM50204718 | |||
| n/a | |||
| Name | BDBM50204718 | ||
| Synonyms: | (1r,4r)-4-methyl-N-((3-p-tolyl-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl)cyclohexanamine | CHEMBL395307 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H29N3 | ||
| Mol. Mass. | 371.5179 | ||
| SMILES | C[C@H]1CC[C@@H](CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(C)cc2)c1 |wU:4.7,wD:1.0,(17.31,-30.76,;18.65,-30,;19.98,-30.77,;21.32,-30.01,;21.33,-28.47,;19.99,-27.7,;18.66,-28.46,;22.66,-27.71,;23.99,-28.48,;25.33,-27.71,;25.33,-26.16,;26.66,-25.39,;27.99,-26.16,;27.99,-27.71,;29.47,-28.19,;30.38,-26.94,;31.86,-26.46,;31.86,-24.9,;30.38,-24.42,;29.47,-25.68,;33.1,-27.36,;32.94,-28.89,;34.18,-29.8,;35.59,-29.17,;36.84,-30.08,;35.75,-27.64,;34.5,-26.74,;26.66,-28.48,)| | ||
| Structure | 
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