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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Chk1 | ||
| Ligand | BDBM50204709 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_442099 (CHEMBL891237) | ||
| IC50 | 1042±n/a nM | ||
| Citation |  Tong, Y; Claiborne, A; Stewart, KD; Park, C; Kovar, P; Chen, Z; Credo, RB; Gu, WZ; Gwaltney, SL; Judge, RA; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Chk1 | |||
| Name: | Serine/threonine-protein kinase Chk1 | ||
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 54443.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_166295192 | ||
| Residue: | 476 | ||
| Sequence: |
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| BDBM50204709 | |||
| n/a | |||
| Name | BDBM50204709 | ||
| Synonyms: | 4-(6-(((1r,4r)-4-methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzenamine | CHEMBL390222 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H28N4 | ||
| Mol. Mass. | 372.5059 | ||
| SMILES | C[C@H]1CC[C@@H](CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(N)cc2)c1 |wU:4.7,wD:1.0,(-9.34,-20.62,;-8.01,-19.86,;-6.68,-20.63,;-5.34,-19.87,;-5.33,-18.33,;-6.67,-17.56,;-8,-18.32,;-4,-17.57,;-2.67,-18.34,;-1.33,-17.57,;-1.33,-16.02,;-0,-15.25,;1.33,-16.02,;1.33,-17.57,;2.81,-18.05,;3.72,-16.8,;5.2,-16.32,;5.2,-14.76,;3.72,-14.28,;2.8,-15.54,;6.44,-17.22,;6.28,-18.75,;7.52,-19.66,;8.93,-19.03,;10.17,-19.94,;9.08,-17.5,;7.84,-16.6,;-0,-18.34,)| | ||
| Structure | 
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