Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase Chk1

Ligand

BDBM50204692

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_442099 (CHEMBL891237)

IC50

481±n/a nM

Citation

Tong, Y; Claiborne, A; Stewart, KD; Park, C; Kovar, P; Chen, Z; Credo, RB; Gu, WZ; Gwaltney, SL; Judge, RA; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase Chk1

Name:

Serine/threonine-protein kinase Chk1

Synonyms:

CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

54443.02

Organism:

Homo sapiens (Human)

Description:

gi_166295192

Residue:

476

Sequence:

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT

BDBM50204692

n/a

Name

BDBM50204692

Synonyms:

(1r,4r)-N-((3-(4-chlorophenyl)-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl)-4-methylcyclohexanamine | CHEMBL390024

Type

Small organic molecule

Emp. Form.

C24H26ClN3

Mol. Mass.

391.936

SMILES

C[C@H]1CC[C@@H](CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(Cl)cc2)c1 |wU:4.7,wD:1.0,(14.86,-11.88,;16.2,-11.11,;17.53,-11.89,;18.87,-11.12,;18.88,-9.59,;17.54,-8.81,;16.21,-9.58,;20.21,-8.82,;21.54,-9.59,;22.87,-8.82,;22.88,-7.28,;24.2,-6.51,;25.54,-7.27,;25.54,-8.82,;27.01,-9.3,;27.93,-8.06,;29.41,-7.58,;29.41,-6.02,;27.93,-5.54,;27.01,-6.8,;30.65,-8.48,;30.48,-10.01,;31.73,-10.92,;33.13,-10.29,;34.38,-11.2,;33.29,-8.75,;32.05,-7.85,;24.21,-9.6,)|

Structure