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TargetSerine/threonine-protein kinase Chk1
LigandBDBM50204727
Substrate/Competitorn/a
Meas. Tech.ChEMBL_442099 (CHEMBL891237)
IC50 790±n/a nM
Citation Tong, YClaiborne, AStewart, KDPark, CKovar, PChen, ZCredo, RBGu, WZGwaltney, SLJudge, RAZhang, HRosenberg, SHSham, HLSowin, TJLin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Chk1
Name:Serine/threonine-protein kinase Chk1
Synonyms:CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:Enzyme Catalytic Domain
Mol. Mass.:54443.02
Organism:Homo sapiens (Human)
Description:gi_166295192
Residue:476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50204727
n/a
NameBDBM50204727
Synonyms:(4-(6-(((1r,4r)-4-methylcyclohexylamino)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenyl)methanol | CHEMBL243817
TypeSmall organic molecule
Emp. Form.C25H29N3O
Mol. Mass.387.5173
SMILESC[C@H]1CC[C@@H](CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(CO)cc2)c1 |wU:4.7,wD:1.0,(-8.3,-29.74,;-6.96,-28.97,;-5.63,-29.75,;-4.29,-28.98,;-4.28,-27.45,;-5.62,-26.67,;-6.95,-27.43,;-2.95,-26.68,;-1.62,-27.45,;-.28,-26.68,;-.28,-25.14,;1.05,-24.37,;2.38,-25.13,;2.38,-26.68,;3.86,-27.16,;4.77,-25.91,;6.25,-25.43,;6.25,-23.88,;4.77,-23.39,;3.85,-24.65,;7.49,-26.34,;7.33,-27.87,;8.57,-28.77,;9.98,-28.15,;11.22,-29.05,;12.63,-28.43,;10.14,-26.61,;8.89,-25.71,;1.05,-27.45,)|
Structure
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