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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Chk1 | ||
| Ligand | BDBM50204719 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_442102 (CHEMBL891240) | ||
| EC50 | >59000±n/a nM | ||
| Citation |  Tong, Y; Claiborne, A; Stewart, KD; Park, C; Kovar, P; Chen, Z; Credo, RB; Gu, WZ; Gwaltney, SL; Judge, RA; Zhang, H; Rosenberg, SH; Sham, HL; Sowin, TJ; Lin, NH Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem15:2759-67 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Chk1 | |||
| Name: | Serine/threonine-protein kinase Chk1 | ||
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 54443.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_166295192 | ||
| Residue: | 476 | ||
| Sequence: |
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| BDBM50204719 | |||
| n/a | |||
| Name | BDBM50204719 | ||
| Synonyms: | 4-(6-(((1r,4r)-4-hydroxycyclohexyl)carbamoyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid | CHEMBL242523 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23N3O4 | ||
| Mol. Mass. | 417.4571 | ||
| SMILES | O[C@H]1CC[C@@H](CC1)NC(=O)c1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)C(O)=O)c1 |wU:4.7,wD:1.0,(16.94,-33.49,;18.28,-32.72,;19.61,-33.49,;20.95,-32.71,;20.93,-31.18,;19.6,-30.41,;18.28,-31.18,;22.26,-30.4,;23.59,-31.16,;23.6,-32.7,;24.92,-30.39,;24.92,-28.84,;26.24,-28.06,;27.58,-28.82,;27.59,-30.37,;29.07,-30.84,;29.97,-29.59,;31.45,-29.1,;31.44,-27.54,;29.96,-27.06,;29.05,-28.33,;32.7,-29.99,;32.54,-31.52,;33.79,-32.42,;35.2,-31.79,;35.34,-30.25,;34.09,-29.36,;36.45,-32.69,;37.85,-32.05,;36.3,-34.22,;26.26,-31.15,)| | ||
| Structure | 
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