| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase |
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| Ligand | BDBM50205239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_428150 (CHEMBL915787) |
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| IC50 | >500000±n/a nM |
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| Citation |  Chitneni, SK; Deroose, CM; Balzarini, J; Gijsbers, R; Celen, SJ; de Groot, TJ; Debyser, Z; Mortelmans, L; Verbruggen, AM; Bormans, GM Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. J Med Chem50:1041-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase |
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| Name: | Thymidine kinase |
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| Synonyms: | KITH_HHV1 | TK | UL23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40902.47 |
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| Organism: | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
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| Description: | ChEMBL_474154 |
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| Residue: | 376 |
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| Sequence: | MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRLEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWQVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPT
ICDLARTFAREMGEAN
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| BDBM50205239 |
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| n/a |
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| Name | BDBM50205239 |
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| Synonyms: | 3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-(3-hydroxyphenyl)furo[2,3-d]pyrimidin-2(3H)-one | 3-(2'-deoxy-beta-D-ribofuranosyl)-6-(3-hydroxyphenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2-one | CHEMBL375147 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N2O6 |
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| Mol. Mass. | 344.3187 |
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| SMILES | OC[C@H]1O[C@H](C[C@@H]1O)n1cc2cc(oc2nc1=O)-c1cccc(O)c1 |
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| Structure | 
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