Reaction Details |
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Target | Muscarinic acetylcholine receptor M4 |
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Ligand | BDBM50206162 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_454684 (CHEMBL886704) |
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Ki | 300±n/a nM |
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Citation | Suckling, CJ; Murphy, JA; Khalaf, AI; Zhou, SZ; Lizos, DE; van Nhien, AN; Yasumatsu, H; McVie, A; Young, LC; McCraw, C; Waterman, PG; Morris, BJ; Pratt, JA; Harvey, AL M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds. Bioorg Med Chem Lett17:2649-55 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M4 |
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Name: | Muscarinic acetylcholine receptor M4 |
Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 53079.31 |
Organism: | Homo sapiens (Human) |
Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
Residue: | 479 |
Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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BDBM50206162 |
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n/a |
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Name | BDBM50206162 |
Synonyms: | (E)-N-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methylene)-3,4a,9,9a-tetrahydro-2H-indeno[1,2-b][1,4]dithiin-6-amine | CHEMBL240024 |
Type | Small organic molecule |
Emp. Form. | C23H26N2O2S2 |
Mol. Mass. | 426.595 |
SMILES | COc1cc2CCN(Cc2cc1OC)\C=N\c1ccc2CC3SCCSC3c2c1 |w:21.22,26.27| |
Structure |
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