Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M4

Ligand

BDBM50206184

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_454684 (CHEMBL886704)

700±n/a nM

Citation

Suckling, CJ; Murphy, JA; Khalaf, AI; Zhou, SZ; Lizos, DE; van Nhien, AN; Yasumatsu, H; McVie, A; Young, LC; McCraw, C; Waterman, PG; Morris, BJ; Pratt, JA; Harvey, AL M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds. Bioorg Med Chem Lett17:2649-55 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M4

Name:

Muscarinic acetylcholine receptor M4

Synonyms:

ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4

Type:

Enzyme Catalytic Domain

Mol. Mass.:

53079.31

Organism:

Homo sapiens (Human)

Description:

Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173

Residue:

479

Sequence:

MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR

BDBM50206184

n/a

Name

BDBM50206184

Synonyms:

(E)-N-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methylene)-2,3,4a,5,6,10b-hexahydronaphtho[1,2-b][1,4]dithiin-9-amine | CHEMBL241282

Type

Small organic molecule

Emp. Form.

C24H28N2O2S2

Mol. Mass.

440.621

SMILES

COc1cc2CCN(Cc2cc1OC)\C=N\c1ccc2CCC3SCCSC3c2c1 |w:22.23,27.28|

Structure