| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 3 |
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| Ligand | BDBM50208115 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_429282 (CHEMBL915841) |
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| EC50 | 4900±n/a nM |
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| Citation |  Jung, JK; Johnson, BR; Duong, T; Decaire, M; Uy, J; Gharbaoui, T; Boatman, PD; Sage, CR; Chen, R; Richman, JG; Connolly, DT; Semple, G Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem50:1445-8 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 3 |
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| Name: | Hydroxycarboxylic acid receptor 3 |
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| Synonyms: | G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44498.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | GPR109B 0 HUMAN::P49019 |
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| Residue: | 387 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISF
SICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGP
TSNNHSKKGHCHQEPASLEKQLGCCIE
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| BDBM50208115 |
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| n/a |
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| Name | BDBM50208115 |
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| Synonyms: | (+)-5-(3-bromo-phenyl)-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid | (-)-5-(3-bromo-phenyl)-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid | 5-(3-bromo-phenyl)-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid | CHEMBL219980 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9BrO4 |
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| Mol. Mass. | 297.101 |
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| SMILES | CC1(OC(=CC1=O)C(O)=O)c1cccc(Br)c1 |c:3| |
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| Structure | 
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