| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 3 |
|---|
| Ligand | BDBM50208139 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_429282 (CHEMBL915841) |
|---|
| EC50 | 4200±n/a nM |
|---|
| Citation |  Jung, JK; Johnson, BR; Duong, T; Decaire, M; Uy, J; Gharbaoui, T; Boatman, PD; Sage, CR; Chen, R; Richman, JG; Connolly, DT; Semple, G Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem50:1445-8 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hydroxycarboxylic acid receptor 3 |
|---|
| Name: | Hydroxycarboxylic acid receptor 3 |
|---|
| Synonyms: | G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 44498.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | GPR109B 0 HUMAN::P49019 |
|---|
| Residue: | 387 |
|---|
| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISF
SICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGP
TSNNHSKKGHCHQEPASLEKQLGCCIE
|
|
|
|---|
| BDBM50208139 |
|---|
| n/a |
|---|
| Name | BDBM50208139 |
|---|
| Synonyms: | 5-methyl-4-oxo-5-thiophen-3-yl-4,5-dihydro-furan-2-carboxylic acid | CHEMBL223140 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H8O4S |
|---|
| Mol. Mass. | 224.233 |
|---|
| SMILES | CC1(OC(=CC1=O)C(O)=O)c1ccsc1 |c:3| |
|---|
| Structure | 
|
|---|
Search and Browse
