| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM50202318 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_436055 (CHEMBL905460) |
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| IC50 | 81000±n/a nM |
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| Citation |  Iturriaga-Vásquez, P; Pérez, EG; Slater, EY; Bermúdez, I; Cassels, BK Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. Bioorg Med Chem15:3368-72 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) |
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| Type: | n/a |
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| Mol. Mass.: | 56448.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | CHRNA7 (NACHRA7) |
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| Residue: | 502 |
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| Sequence: | MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM50202318 |
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| n/a |
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| Name | BDBM50202318 |
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| Synonyms: | (+)-boldine | (S)-(+)-Boldine | (S)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol | CHEMBL388342 | boldine | cid_10154 | cid_248507 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21NO4 |
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| Mol. Mass. | 327.3743 |
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| SMILES | COc1cc-2c(C[C@@H]3N(C)CCc4cc(O)c(OC)c-2c34)cc1O |r| |
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| Structure | 
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