| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C9 |
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| Ligand | BDBM50209512 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_455271 (CHEMBL886047) |
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| IC50 | 66±n/a nM |
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| Citation |  Cantin, LD; Magnuson, S; Gunn, D; Barucci, N; Breuhaus, M; Bullock, WH; Burke, J; Claus, TH; Daly, M; Decarr, L; Gore-Willse, A; Hoover-Litty, H; Kumarasinghe, ES; Li, Y; Liang, SX; Livingston, JN; Lowinger, T; Macdougall, M; Ogutu, HO; Olague, A; Ott-Morgan, R; Schoenleber, RW; Tersteegen, A; Wickens, P; Zhang, Z; Zhu, J; Zhu, L; Sweet, LJ PDE-10A inhibitors as insulin secretagogues. Bioorg Med Chem Lett17:2869-73 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C9 |
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| Name: | Cytochrome P450 2C9 |
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| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 55636.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11712 |
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| Residue: | 490 |
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| Sequence: | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
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| BDBM50209512 |
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| n/a |
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| Name | BDBM50209512 |
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| Synonyms: | (S)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-quinolin-4-ylamino]-propionic acid | CHEMBL397600 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22FN3O3 |
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| Mol. Mass. | 455.4803 |
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| SMILES | CCOc1ccccc1-c1ccc(cc1)-c1nc2ccc(F)cc2c(N[C@@H](C)C(O)=O)c1C#N |
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| Structure | 
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