Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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Ligand | BDBM50210892 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_455483 (CHEMBL886262) |
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Ki | 140±n/a nM |
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Citation | Flyrén, K; Bergquist, LO; Castro, VM; Fotsch, C; Johansson, L; St Jean, DJ; Sutin, L; Williams, M Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors. Bioorg Med Chem Lett17:3421-5 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase 1 |
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Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
Type: | Enzyme |
Mol. Mass.: | 32409.16 |
Organism: | Homo sapiens (Human) |
Description: | P28845 |
Residue: | 292 |
Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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BDBM50210892 |
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n/a |
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Name | BDBM50210892 |
Synonyms: | 1-(1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2(3H)-one | CHEMBL399456 |
Type | Small organic molecule |
Emp. Form. | C22H25N3O3 |
Mol. Mass. | 379.4522 |
SMILES | COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2cccc(C)c2[nH]c1=O |
Structure |
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