Reaction Details |
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Target | Thymidine kinase |
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Ligand | BDBM50205239 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_455486 (CHEMBL886265) |
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IC50 | 2600±n/a nM |
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Citation | Chitneni, SK; Deroose, CM; Fonge, H; Gijsbers, R; Dyubankova, N; Balzarini, J; Debyser, Z; Mortelmans, L; Verbruggen, AM; Bormans, GM Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging. Bioorg Med Chem Lett17:3458-62 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thymidine kinase |
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Name: | Thymidine kinase |
Synonyms: | KITH_VZVD | TK |
Type: | PROTEIN |
Mol. Mass.: | 37819.99 |
Organism: | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
Description: | ChEMBL_444706 |
Residue: | 341 |
Sequence: | MSTDKTDVKMGVLRIYLDGAYGIGKTTAAEEFLHHFAITPNRILLIGEPLSYWRNLAGED
AICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNK
EPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTVSLPSH
LSRVSKRARPGETVNLPFVMVLRNVYIMLINTIIFLKTNNWHAGWNTLSFCNDVFKQKLQ
KSECIKLREVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCSRSMSPFVLSLEQ
TPQHAAQELKTLLPQMTPANMSSGAWNILKELVNAVQDNTS
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BDBM50205239 |
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n/a |
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Name | BDBM50205239 |
Synonyms: | 3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-(3-hydroxyphenyl)furo[2,3-d]pyrimidin-2(3H)-one | 3-(2'-deoxy-beta-D-ribofuranosyl)-6-(3-hydroxyphenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2-one | CHEMBL375147 |
Type | Small organic molecule |
Emp. Form. | C17H16N2O6 |
Mol. Mass. | 344.3187 |
SMILES | OC[C@H]1O[C@H](C[C@@H]1O)n1cc2cc(oc2nc1=O)-c1cccc(O)c1 |
Structure |
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