Reaction Details |
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Target | Transcription factor Jun |
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Ligand | BDBM50211430 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_455594 (CHEMBL886374) |
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IC50 | 813±n/a nM |
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Citation | Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett17:3463-7 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transcription factor Jun |
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Name: | Transcription factor Jun |
Synonyms: | AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39 |
Type: | n/a |
Mol. Mass.: | 35683.24 |
Organism: | Homo sapiens (Human) |
Description: | P05412 |
Residue: | 331 |
Sequence: | MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
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BDBM50211430 |
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n/a |
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Name | BDBM50211430 |
Synonyms: | (4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidin-1-yl)(4-methylpiperidin-1-yl)methanone | CHEMBL245733 |
Type | Small organic molecule |
Emp. Form. | C24H29ClN6O |
Mol. Mass. | 452.98 |
SMILES | CC1CCN(CC1)C(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 |
Structure |
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