| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50211563 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_438714 (CHEMBL889048) |
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| Ki | 0.24±n/a nM |
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| Citation |  Dönnecke, D; Schweinitz, A; Stürzebecher, A; Steinmetzer, P; Schuster, M; Stürzebecher, U; Nicklisch, S; Stürzebecher, J; Steinmetzer, T From selective substrate analogue factor Xa inhibitors to dual inhibitors of thrombin and factor Xa. Part 3. Bioorg Med Chem Lett17:3322-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50211563 |
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| n/a |
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| Name | BDBM50211563 |
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| Synonyms: | (S)-4-(2-aminomethyl-5-chloro-benzylcarbamoyl)-4-{methoxy-[(R)-4-(1-oxy-pyridin-2-yl)-2-phenylmethanesulfonylamino-butyryl]-amino}-butyric acid | CHEMBL397895 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H36ClN5O8S |
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| Mol. Mass. | 662.154 |
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| SMILES | CON([C@@H](CCC(O)=O)C(=O)NCc1cc(Cl)ccc1CN)C(=O)[C@@H](CCc1cccc[n+]1[O-])NS(=O)(=O)Cc1ccccc1 |
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| Structure | 
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