| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50211552 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_438714 (CHEMBL889048) |
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| Ki | 0.35±n/a nM |
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| Citation |  Dönnecke, D; Schweinitz, A; Stürzebecher, A; Steinmetzer, P; Schuster, M; Stürzebecher, U; Nicklisch, S; Stürzebecher, J; Steinmetzer, T From selective substrate analogue factor Xa inhibitors to dual inhibitors of thrombin and factor Xa. Part 3. Bioorg Med Chem Lett17:3322-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50211552 |
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| n/a |
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| Name | BDBM50211552 |
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| Synonyms: | (4-{[1-{[(2-aminomethyl-5-chloro-benzylcarbamoyl)-methyl]-carbamoyl}-3-(1-oxy-pyridin-2-yl)-propylsulfamoyl]-methyl}-phenyl)-acetic acid methyl ester | CHEMBL442228 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H34ClN5O7S |
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| Mol. Mass. | 632.128 |
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| SMILES | COC(=O)Cc1ccc(CS(=O)(=O)NC(CCc2cccc[n+]2[O-])C(=O)NCC(=O)NCc2cc(Cl)ccc2CN)cc1 |w:14.14| |
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| Structure | 
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