| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 2 |
|---|
| Ligand | BDBM50214433 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_439074 (CHEMBL889422) |
|---|
| IC50 | 647±n/a nM |
|---|
| Citation |  Kozikowski, AP; Chen, Y; Gaysin, A; Chen, B; D'Annibale, MA; Suto, CM; Langley, BC Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies. J Med Chem50:3054-61 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 2 |
|---|
| Name: | Histone deacetylase 2 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 55356.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q92769 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
|
|
|
|---|
| BDBM50214433 |
|---|
| n/a |
|---|
| Name | BDBM50214433 |
|---|
| Synonyms: | 1-(4-(dimethylamino)phenyl)-3-(7-(hydroxyamino)-7-oxoheptyl)urea | 7-[3-(4-dimethylaminophenyl)-ureido]heptanoic acid hydroxyamide | CHEMBL227120 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H26N4O3 |
|---|
| Mol. Mass. | 322.4026 |
|---|
| SMILES | CN(C)c1ccc(NC(=O)NCCCCCCC(=O)NO)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
