| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 8 |
|---|
| Ligand | BDBM50214438 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_439075 (CHEMBL889423) |
|---|
| IC50 | 13900±n/a nM |
|---|
| Citation |  Kozikowski, AP; Chen, Y; Gaysin, A; Chen, B; D'Annibale, MA; Suto, CM; Langley, BC Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies. J Med Chem50:3054-61 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 8 |
|---|
| Name: | Histone deacetylase 8 |
|---|
| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41749.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BY41 |
|---|
| Residue: | 377 |
|---|
| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
|
|
|
|---|
| BDBM50214438 |
|---|
| n/a |
|---|
| Name | BDBM50214438 |
|---|
| Synonyms: | 1-(6-(2-mercaptoacetamido)hexyl)-3-phenylurea | 2-Mercapto-N-[6-(3-phenyl-ureido)-hexyl]-acetamide | 2-mercapto-N-[6-(3-phenyl-ureido)-hexyl]acetamide | CHEMBL427135 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H23N3O2S |
|---|
| Mol. Mass. | 309.427 |
|---|
| SMILES | SCC(=O)NCCCCCCNC(=O)Nc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
