| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2 |
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| Ligand | BDBM50214440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_439074 (CHEMBL889422) |
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| IC50 | 4640±n/a nM |
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| Citation |  Kozikowski, AP; Chen, Y; Gaysin, A; Chen, B; D'Annibale, MA; Suto, CM; Langley, BC Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies. J Med Chem50:3054-61 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 2 |
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| Name: | Histone deacetylase 2 |
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| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 55356.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92769 |
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| Residue: | 488 |
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| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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| BDBM50214440 |
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| n/a |
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| Name | BDBM50214440 |
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| Synonyms: | 4-(dimethylamino)-N-(6-(2-mercaptoacetamido)hexyl)benzamide | 4-Dimethylamino-N-[6-(2-mercapto-acetylamino)-hexyl]-benzamide | 4-dimethylamino-N-[6-(2-mercaptoacetylamino)hexyl]benzamide | CHEMBL440018 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H27N3O2S |
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| Mol. Mass. | 337.48 |
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| SMILES | CN(C)c1ccc(cc1)C(=O)NCCCCCCNC(=O)CS |
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| Structure | 
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