Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-2 |
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Ligand | BDBM50216691 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_437199 (CHEMBL906597) |
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IC50 | 5500±n/a nM |
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Citation | Outeiro, TF; Kontopoulos, E; Altmann, SM; Kufareva, I; Strathearn, KE; Amore, AM; Volk, CB; Maxwell, MM; Rochet, JC; McLean, PJ; Young, AB; Abagyan, R; Feany, MB; Hyman, BT; Kazantsev, AG Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science317:516-9 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-2 |
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Name: | NAD-dependent protein deacetylase sirtuin-2 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
Type: | Hydrolase |
Mol. Mass.: | 43172.62 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 389 |
Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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BDBM50216691 |
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n/a |
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Name | BDBM50216691 |
Synonyms: | 3-(5-(2-chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamide | CHEMBL228175 |
Type | Small organic molecule |
Emp. Form. | C23H14ClN3O2 |
Mol. Mass. | 399.829 |
SMILES | Clc1ccccc1-c1ccc(\C=C(/C#N)C(=O)Nc2cccc3ncccc23)o1 |
Structure |
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