| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Ligand | BDBM50216690 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_437200 (CHEMBL906598) |
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| IC50 | >50000±n/a nM |
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| Citation |  Outeiro, TF; Kontopoulos, E; Altmann, SM; Kufareva, I; Strathearn, KE; Amore, AM; Volk, CB; Maxwell, MM; Rochet, JC; McLean, PJ; Young, AB; Abagyan, R; Feany, MB; Hyman, BT; Kazantsev, AG Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science317:516-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Synonyms: | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3 |
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| Type: | Protein |
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| Mol. Mass.: | 43582.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NTG7 |
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| Residue: | 399 |
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| Sequence: | MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
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| BDBM50216690 |
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| n/a |
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| Name | BDBM50216690 |
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| Synonyms: | 2-cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-8-yl)acrylamide | CHEMBL226027 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H13Cl2N3O2 |
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| Mol. Mass. | 434.274 |
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| SMILES | Clc1cccc(-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4cccnc34)o2)c1Cl |
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| Structure | 
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