| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 8 |
|---|
| Ligand | BDBM50217030 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_440407 (CHEMBL890721) |
|---|
| EC50 | 2150±n/a nM |
|---|
| Citation |  Sibille, P; Lopez, S; Brabet, I; Valenti, O; Oueslati, N; Gaven, F; Goudet, C; Bertrand, HO; Neyton, J; Marino, MJ; Amalric, M; Pin, JP; Acher, FC Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists. J Med Chem50:3585-95 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 8 |
|---|
| Name: | Metabotropic glutamate receptor 8 |
|---|
| Synonyms: | GPRC1H | GRM8 | GRM8_HUMAN | MGLUR8 | Metabotropic glutamate receptor 8 | metabotropic glutamate 8 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 101759.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | metabotropic glutamate 8 GRM8 HUMAN::O00222 |
|---|
| Residue: | 908 |
|---|
| Sequence: | MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
|
|
|
|---|
| BDBM50217030 |
|---|
| n/a |
|---|
| Name | BDBM50217030 |
|---|
| Synonyms: | (1S,2S)-1-amino-2-phosphonomethylcyclopropane-carboxylic acid | CHEMBL227288 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C5H10NO5P |
|---|
| Mol. Mass. | 195.1104 |
|---|
| SMILES | N[C@]1(C[C@@H]1CP(O)(O)=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
