Reaction Details | |||
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Target | Melanocyte-stimulating hormone receptor | ||
Ligand | BDBM50217776 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_448689 (CHEMBL896689) | ||
Ki | 2000±n/a nM | ||
Citation | Mutulis, F; Kreicberga, J; Yahorava, S; Mutule, I; Borisova-Jan, L; Yahorau, A; Muceniece, R; Azena, S; Veiksina, S; Petrovska, R; Wikberg, JE Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem15:5787-810 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Melanocyte-stimulating hormone receptor | |||
Name: | Melanocyte-stimulating hormone receptor | ||
Synonyms: | MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r | ||
Type: | PROTEIN | ||
Mol. Mass.: | 35238.60 | ||
Organism: | Mus musculus | ||
Description: | ChEMBL_1498846 | ||
Residue: | 315 | ||
Sequence: |
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BDBM50217776 | |||
n/a | |||
Name | BDBM50217776 | ||
Synonyms: | CHEMBL397324 | N-(2-bromo-4,5-dimethoxycinnamyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide | ||
Type | Small organic molecule | ||
Emp. Form. | C36H48BrN3O3 | ||
Mol. Mass. | 650.689 | ||
SMILES | COc1cc(Br)c(\C=C\CN(C2CCC(CC3CCC(N)CC3)CC2)C(=O)CCCc2c[nH]c3ccccc23)cc1OC |(-9.73,-19.07,;-9.7,-20.61,;-8.36,-21.36,;-8.33,-22.91,;-6.99,-23.65,;-6.96,-25.19,;-5.68,-22.86,;-4.33,-23.61,;-3.01,-22.83,;-1.66,-23.58,;-.34,-22.79,;-.37,-21.23,;.97,-20.44,;.95,-18.89,;-.4,-18.13,;-.42,-16.59,;.9,-15.8,;2.24,-16.57,;3.57,-15.79,;3.56,-14.25,;4.88,-13.47,;2.22,-13.49,;.89,-14.27,;-1.74,-18.92,;-1.73,-20.48,;1.01,-23.55,;1.04,-25.1,;2.34,-22.75,;3.68,-23.48,;5.01,-22.71,;6.34,-23.47,;7.75,-22.8,;8.8,-23.93,;8.05,-25.27,;8.54,-26.72,;7.54,-27.88,;6.03,-27.58,;5.54,-26.13,;6.55,-24.97,;-5.69,-21.32,;-7.04,-20.57,;-7.06,-19.03,;-5.73,-18.24,)| | ||
Structure |