Ki Summary

Reaction Details

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Target

Melanocyte-stimulating hormone receptor

Ligand

BDBM50217670

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_448689 (CHEMBL896689)

1900±n/a nM

Citation

Mutulis, F; Kreicberga, J; Yahorava, S; Mutule, I; Borisova-Jan, L; Yahorau, A; Muceniece, R; Azena, S; Veiksina, S; Petrovska, R; Wikberg, JE Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem15:5787-810 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocyte-stimulating hormone receptor

Name:

Melanocyte-stimulating hormone receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

35238.60

Organism:

Mus musculus

Description:

ChEMBL_1498846

Residue:

315

Sequence:

MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIA
ITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDV
LICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITY
YKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAAT
LTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRS
QELRMTLKEVLLCSW

BDBM50217670

n/a

Name

BDBM50217670

Synonyms:

CHEMBL235176 | N-(3,4-dimethoxybenzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide

Type

Small organic molecule

Emp. Form.

C41H53N3O4

Mol. Mass.

651.8772

SMILES

COc1ccc(CN(C2CCC(CC3CCC(N)CC3)CC2)C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)cc1OC |(-10.93,-16.01,;-10.93,-17.55,;-9.6,-18.32,;-9.59,-19.87,;-8.26,-20.64,;-6.94,-19.87,;-5.6,-20.64,;-4.27,-19.87,;-4.27,-18.31,;-2.92,-17.54,;-2.92,-15.99,;-4.26,-15.2,;-4.25,-13.66,;-2.92,-12.9,;-1.59,-13.69,;-.25,-12.93,;-.24,-11.39,;1.1,-10.63,;-1.57,-10.61,;-2.92,-11.37,;-5.61,-15.98,;-5.62,-17.54,;-2.93,-20.64,;-2.93,-22.2,;-1.58,-19.87,;-.25,-20.63,;1.08,-19.86,;2.42,-20.63,;3,-19.2,;2.18,-17.9,;2.91,-16.54,;4.45,-16.49,;5.17,-15.13,;4.35,-13.82,;5.08,-12.46,;2.81,-13.88,;2.09,-15.24,;4.53,-19.31,;4.91,-20.81,;6.25,-21.53,;6.31,-23.06,;5,-23.87,;3.64,-23.14,;3.6,-21.61,;-6.93,-18.32,;-8.26,-17.55,;-8.26,-16.01,;-9.59,-15.24,)|

Structure