Ki Summary

Reaction Details

Report a problem with these data

Target

Melanocyte-stimulating hormone receptor

Ligand

BDBM50217786

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_448689 (CHEMBL896689)

2400±n/a nM

Citation

Mutulis, F; Kreicberga, J; Yahorava, S; Mutule, I; Borisova-Jan, L; Yahorau, A; Muceniece, R; Azena, S; Veiksina, S; Petrovska, R; Wikberg, JE Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem15:5787-810 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocyte-stimulating hormone receptor

Name:

Melanocyte-stimulating hormone receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

35238.60

Organism:

Mus musculus

Description:

ChEMBL_1498846

Residue:

315

Sequence:

MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIA
ITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDV
LICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITY
YKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAAT
LTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRS
QELRMTLKEVLLCSW

BDBM50217786

n/a

Name

BDBM50217786

Synonyms:

CHEMBL237070 | N-(2-fluorobenzyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide

Type

Small organic molecule

Emp. Form.

C32H42FN3O

Mol. Mass.

503.6938

SMILES

NC1CCC(CC2CCC(CC2)N(Cc2ccccc2F)C(=O)CCCc2c[nH]c3ccccc23)CC1 |(1.33,-26.36,;-.01,-27.12,;-.02,-28.66,;-1.35,-29.42,;-2.68,-28.63,;-4.02,-29.4,;-4.03,-30.94,;-2.68,-31.72,;-2.69,-33.27,;-4.04,-34.05,;-5.38,-33.27,;-5.38,-31.71,;-4.04,-35.6,;-5.37,-36.37,;-6.7,-35.6,;-6.7,-34.06,;-8.03,-33.29,;-9.36,-34.06,;-9.36,-35.61,;-8.03,-36.37,;-8.02,-37.91,;-2.69,-36.38,;-2.69,-37.93,;-1.35,-35.6,;-.02,-36.37,;1.32,-35.59,;2.65,-36.36,;3.23,-34.94,;4.77,-35.04,;5.14,-36.54,;6.49,-37.26,;6.54,-38.79,;5.23,-39.61,;3.88,-38.88,;3.83,-37.35,;-2.68,-27.1,;-1.34,-26.34,)|

Structure