Ki Summary

Reaction Details

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Target

Melanocyte-stimulating hormone receptor

Ligand

BDBM50217708

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_448689 (CHEMBL896689)

2100±n/a nM

Citation

Mutulis, F; Kreicberga, J; Yahorava, S; Mutule, I; Borisova-Jan, L; Yahorau, A; Muceniece, R; Azena, S; Veiksina, S; Petrovska, R; Wikberg, JE Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem15:5787-810 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocyte-stimulating hormone receptor

Name:

Melanocyte-stimulating hormone receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

35238.60

Organism:

Mus musculus

Description:

ChEMBL_1498846

Residue:

315

Sequence:

MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIA
ITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDV
LICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITY
YKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAAT
LTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRS
QELRMTLKEVLLCSW

BDBM50217708

n/a

Name

BDBM50217708

Synonyms:

CHEMBL235358 | N-(2-chloro-6-fluorophenethyl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)-4-(1H-indol-3-yl)butanamide

Type

Small organic molecule

Emp. Form.

C33H43ClFN3O

Mol. Mass.

552.165

SMILES

NC1CCC(CC2CCC(CC2)N(CCc2c(F)cccc2Cl)C(=O)CCCc2c[nH]c3ccccc23)CC1 |(40.94,4.39,;39.61,3.61,;39.63,2.07,;38.3,1.29,;36.96,2.06,;35.64,1.27,;35.66,-.27,;37.01,-1.03,;37.03,-2.58,;35.69,-3.37,;34.33,-2.62,;34.32,-1.06,;35.71,-4.93,;34.39,-5.72,;34.42,-7.26,;33.1,-8.05,;31.76,-7.3,;31.74,-5.76,;30.44,-8.09,;30.46,-9.63,;31.82,-10.38,;33.13,-9.58,;34.48,-10.32,;37.07,-5.69,;37.09,-7.24,;38.4,-4.89,;39.74,-5.63,;41.07,-4.86,;42.39,-5.62,;43.81,-4.95,;44.86,-6.07,;44.11,-7.42,;44.6,-8.86,;43.6,-10.02,;42.08,-9.72,;41.59,-8.27,;42.61,-7.11,;36.95,3.59,;38.27,4.37,)|

Structure