Ki Summary

Reaction Details

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Target

Melanocyte-stimulating hormone receptor

Ligand

BDBM50217738

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_448689 (CHEMBL896689)

1600±n/a nM

Citation

Mutulis, F; Kreicberga, J; Yahorava, S; Mutule, I; Borisova-Jan, L; Yahorau, A; Muceniece, R; Azena, S; Veiksina, S; Petrovska, R; Wikberg, JE Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem15:5787-810 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocyte-stimulating hormone receptor

Name:

Melanocyte-stimulating hormone receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

35238.60

Organism:

Mus musculus

Description:

ChEMBL_1498846

Residue:

315

Sequence:

MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIA
ITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDV
LICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITY
YKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAAT
LTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRS
QELRMTLKEVLLCSW

BDBM50217738

n/a

Name

BDBM50217738

Synonyms:

CHEMBL237698 | N-(2,6-dichlorobenzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide

Type

Small organic molecule

Emp. Form.

C39H47Cl2N3O2

Mol. Mass.

660.715

SMILES

NC1CCC(CC2CCC(CC2)N(Cc2c(Cl)cccc2Cl)C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)CC1 |(16.09,-32.96,;14.76,-33.74,;14.77,-35.28,;13.45,-36.06,;12.1,-35.29,;10.78,-36.08,;10.8,-37.62,;12.15,-38.38,;12.17,-39.93,;10.83,-40.72,;9.47,-39.97,;9.46,-38.41,;10.86,-42.28,;9.5,-43.24,;9.52,-46,;10.86,-46.76,;12.19,-45.96,;10.9,-48.29,;9.58,-49.08,;8.23,-48.33,;8.2,-46.79,;6.86,-46.04,;12.21,-43.04,;12.24,-44.59,;13.54,-42.24,;14.88,-42.98,;16.22,-42.21,;17.54,-42.97,;18.95,-42.3,;19.71,-40.96,;21.25,-40.94,;22.03,-42.27,;23.57,-42.26,;24.33,-40.92,;25.87,-40.91,;23.54,-39.59,;22,-39.61,;20,-43.42,;19.25,-44.77,;19.75,-46.21,;18.74,-47.37,;17.23,-47.07,;16.74,-45.62,;17.75,-44.47,;12.09,-33.76,;13.42,-32.98,)|

Structure