Ki Summary

Reaction Details

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Target

Melanocyte-stimulating hormone receptor

Ligand

BDBM50217775

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_448689 (CHEMBL896689)

2100±n/a nM

Citation

Mutulis, F; Kreicberga, J; Yahorava, S; Mutule, I; Borisova-Jan, L; Yahorau, A; Muceniece, R; Azena, S; Veiksina, S; Petrovska, R; Wikberg, JE Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem15:5787-810 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocyte-stimulating hormone receptor

Name:

Melanocyte-stimulating hormone receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

35238.60

Organism:

Mus musculus

Description:

ChEMBL_1498846

Residue:

315

Sequence:

MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIA
ITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDV
LICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITY
YKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAAT
LTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRS
QELRMTLKEVLLCSW

BDBM50217775

n/a

Name

BDBM50217775

Synonyms:

CHEMBL394073 | N-(2,6-difluorobenzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide

Type

Small organic molecule

Emp. Form.

C39H47F2N3O2

Mol. Mass.

627.8062

SMILES

NC1CCC(CC2CCC(CC2)N(Cc2c(F)cccc2F)C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)CC1 |(-.63,5.55,;-1.96,4.77,;-1.94,3.23,;-3.27,2.45,;-4.61,3.22,;-5.93,2.43,;-5.92,.89,;-4.56,.13,;-4.54,-1.42,;-5.88,-2.21,;-7.25,-1.46,;-7.25,.1,;-5.86,-3.77,;-7.22,-4.73,;-7.19,-7.49,;-8.51,-8.28,;-9.86,-7.53,;-8.49,-9.82,;-7.13,-10.57,;-5.82,-9.78,;-5.85,-8.24,;-4.53,-7.45,;-4.5,-4.53,;-4.48,-6.08,;-3.17,-3.73,;-1.84,-4.47,;-.5,-3.7,;.82,-4.46,;2.24,-3.79,;3,-2.45,;4.54,-2.43,;5.31,-3.76,;6.85,-3.75,;7.61,-2.41,;9.15,-2.4,;6.82,-1.08,;5.29,-1.1,;3.29,-4.91,;2.54,-6.26,;3.03,-7.7,;2.03,-8.86,;.51,-8.56,;.02,-7.11,;1.03,-5.95,;-4.63,4.75,;-3.3,5.53,)|

Structure