| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50218100 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_457011 (CHEMBL923354) |
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| Ki | 8.9±n/a nM |
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| Citation |  Tran, JA; Chen, CW; Jiang, W; Tucci, FC; Fleck, BA; Marinkovic, D; Arellano, M; Chen, C Pyrrolidines as potent functional agonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett17:5165-70 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50218100 |
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| n/a |
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| Name | BDBM50218100 |
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| Synonyms: | 2-amino-N-((S)-1-(2-(4-((3R,4S)-3-(4-chlorophenyl)-1-isopropylpyrrolidine-4-carbonyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-3-methylbutyl)acetamide | CHEMBL400933 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H43ClF3N5O2 |
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| Mol. Mass. | 622.164 |
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| SMILES | CC(C)C[C@H](NC(=O)CN)c1cc(ccc1N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1)C(C)C)C(F)(F)F |
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| Structure | 
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