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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Aurora kinase C | ||
| Ligand | BDBM50191405 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_445191 (CHEMBL894339) | ||
| IC50 | 700±n/a nM | ||
| Citation |  Myrianthopoulos, V; Magiatis, P; Ferandin, Y; Skaltsounis, AL; Meijer, L; Mikros, E An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. J Med Chem50:4027-37 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Aurora kinase C | |||
| Name: | Aurora kinase C | ||
| Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 35602.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. | ||
| Residue: | 309 | ||
| Sequence: |
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| BDBM50191405 | |||
| n/a | |||
| Name | BDBM50191405 | ||
| Synonyms: | (2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H10BrN3O2 | ||
| Mol. Mass. | 356.174 | ||
| SMILES | Oc1[nH]c2c(Br)cccc2c1-c1[nH]c2ccccc2c1N=O |(-1.26,-17.11,;-.79,-15.64,;.68,-15.16,;.67,-13.63,;1.81,-12.6,;3.27,-13.08,;1.49,-11.1,;.02,-10.63,;-1.11,-11.66,;-.79,-13.15,;-1.69,-14.4,;-3.23,-14.4,;-4.14,-15.67,;-5.62,-15.19,;-6.96,-15.96,;-8.3,-15.19,;-8.3,-13.64,;-6.96,-12.87,;-5.63,-13.63,;-4.15,-13.15,;-3.67,-11.68,;-4.97,-10.17,)| | ||
| Structure | 
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