Reaction Details | |||
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Target | Aurora kinase A | ||
Ligand | BDBM50191448 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_445189 (CHEMBL894337) | ||
IC50 | 2000±n/a nM | ||
Citation | Myrianthopoulos, V; Magiatis, P; Ferandin, Y; Skaltsounis, AL; Meijer, L; Mikros, E An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. J Med Chem50:4027-37 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Aurora kinase A | |||
Name: | Aurora kinase A | ||
Synonyms: | AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1 | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 45830.98 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O14965 | ||
Residue: | 403 | ||
Sequence: |
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BDBM50191448 | |||
n/a | |||
Name | BDBM50191448 | ||
Synonyms: | (2'Z,3'E)-7-fluoroindirubin-3'-oxime | CHEMBL212174 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H10FN3O2 | ||
Mol. Mass. | 295.2679 | ||
SMILES | Oc1[nH]c2c(F)cccc2c1-c1[nH]c2ccccc2c1N=O |(1.25,-3.26,;1.73,-1.79,;3.19,-1.31,;3.18,.22,;4.32,1.24,;5.79,.77,;4,2.75,;2.53,3.22,;1.4,2.19,;1.72,.7,;.82,-.55,;-.72,-.55,;-1.62,-1.82,;-3.11,-1.34,;-4.45,-2.11,;-5.79,-1.34,;-5.78,.21,;-4.45,.98,;-3.11,.22,;-1.63,.7,;-1.16,2.17,;-2.25,3.26,)| | ||
Structure |