| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase C |
|---|
| Ligand | BDBM50024792 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_445191 (CHEMBL894339) |
|---|
| IC50 | 700±n/a nM |
|---|
| Citation |  Myrianthopoulos, V; Magiatis, P; Ferandin, Y; Skaltsounis, AL; Meijer, L; Mikros, E An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. J Med Chem50:4027-37 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase C |
|---|
| Name: | Aurora kinase C |
|---|
| Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35602.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. |
|---|
| Residue: | 309 |
|---|
| Sequence: | MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
|
|
|
|---|
| BDBM50024792 |
|---|
| n/a |
|---|
| Name | BDBM50024792 |
|---|
| Synonyms: | CHEMBL209849 | Indirubin-3-Acetoxime |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H13N3O3 |
|---|
| Mol. Mass. | 319.3141 |
|---|
| SMILES | CC(=O)O\N=C1/C(=Nc2ccccc12)c1c(O)[nH]c2ccccc12 |c:6| |
|---|
| Structure | 
|
|---|
Search and Browse
