Ki Summary

Reaction Details

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Target

Aurora kinase C

Ligand

BDBM50132003

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_445191 (CHEMBL894339)

IC50

300±n/a nM

Citation

Myrianthopoulos, V; Magiatis, P; Ferandin, Y; Skaltsounis, AL; Meijer, L; Mikros, E An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. J Med Chem50:4027-37 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Aurora kinase C

Name:

Aurora kinase C

Synonyms:

Type:

Enzyme

Mol. Mass.:

35602.43

Organism:

Homo sapiens (Human)

Description:

Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system.

Residue:

309

Sequence:

MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS

BDBM50132003

n/a

Name

BDBM50132003

Synonyms:

(Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-oxime | (Z)-1H,1'H-[2,3']Biindolylidene-3,2'-dione 3-oxime | 1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-oxime | 1H,1'H-[2,3']Biindolylidene-3,2'-dione 3-oxime | 3-(3-(hydroxyimino)indolin-2-ylidene)indolin-2-one | CHEMBL126077

Type

Small organic molecule

Emp. Form.

C16H11N3O2

Mol. Mass.

277.2774

SMILES

Oc1[nH]c2ccccc2c1-c1[nH]c2ccccc2c1N=O |(1.71,2.82,;2.18,1.35,;3.65,.86,;3.62,-.68,;4.77,-1.7,;4.44,-3.2,;2.97,-3.66,;1.85,-2.62,;2.18,-1.13,;1.27,.12,;-.27,.12,;-1.18,-1.12,;-2.65,-.64,;-3.96,-1.41,;-5.29,-.64,;-5.29,.9,;-3.96,1.68,;-2.63,.9,;-1.16,1.38,;-.69,2.84,;-1.7,3.98,)|

Structure