Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Aurora kinase B | ||
| Ligand | BDBM50132003 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_445190 (CHEMBL894338) | ||
| IC50 | 2300±n/a nM | ||
| Citation |  Myrianthopoulos, V; Magiatis, P; Ferandin, Y; Skaltsounis, AL; Meijer, L; Mikros, E An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. J Med Chem50:4027-37 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Aurora kinase B | |||
| Name: | Aurora kinase B | ||
| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B | ||
| Type: | Protein | ||
| Mol. Mass.: | 39327.72 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96GD4 | ||
| Residue: | 344 | ||
| Sequence: |
| ||
| BDBM50132003 | |||
| n/a | |||
| Name | BDBM50132003 | ||
| Synonyms: | (Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-oxime | (Z)-1H,1'H-[2,3']Biindolylidene-3,2'-dione 3-oxime | 1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-oxime | 1H,1'H-[2,3']Biindolylidene-3,2'-dione 3-oxime | 3-(3-(hydroxyimino)indolin-2-ylidene)indolin-2-one | CHEMBL126077 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H11N3O2 | ||
| Mol. Mass. | 277.2774 | ||
| SMILES | Oc1[nH]c2ccccc2c1-c1[nH]c2ccccc2c1N=O |(1.71,2.82,;2.18,1.35,;3.65,.86,;3.62,-.68,;4.77,-1.7,;4.44,-3.2,;2.97,-3.66,;1.85,-2.62,;2.18,-1.13,;1.27,.12,;-.27,.12,;-1.18,-1.12,;-2.65,-.64,;-3.96,-1.41,;-5.29,-.64,;-5.29,.9,;-3.96,1.68,;-2.63,.9,;-1.16,1.38,;-.69,2.84,;-1.7,3.98,)| | ||
| Structure | 
| ||