| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50220347 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_446075 (CHEMBL895170) |
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| IC50 | 4500±n/a nM |
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| Citation |  Cisneros, JA; Vandevoorde, S; Ortega-Gutiérrez, S; Paris, C; Fowler, CJ; López-Rodríguez, ML Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. J Med Chem50:5012-23 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL) |
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| Type: | Enzyme |
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| Mol. Mass.: | 33505.38 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q8R431 |
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| Residue: | 303 |
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| Sequence: | MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLG
HSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRID
SSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGAR
CLP
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| BDBM50220347 |
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| n/a |
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| Name | BDBM50220347 |
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| Synonyms: | (+/-)-oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate | CHEMBL244156 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H36O3 |
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| Mol. Mass. | 360.5301 |
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| SMILES | CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OCC1CO1 |w:23.22| |
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| Structure | 
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