| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
|---|
| Ligand | BDBM50222187 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_457756 (CHEMBL924035) |
|---|
| Ki | 1500±n/a nM |
|---|
| Citation |  Boye, SV; Ortega-Caballero, F; Sinning, S; Wiborg, O; Jensen, HH; Bols, M High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors. Bioorg Med Chem Lett17:6019-25 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent dopamine transporter |
|---|
| Name: | Sodium-dependent dopamine transporter |
|---|
| Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 68497.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q01959 |
|---|
| Residue: | 620 |
|---|
| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
|
|
|
|---|
| BDBM50222187 |
|---|
| n/a |
|---|
| Name | BDBM50222187 |
|---|
| Synonyms: | CHEMBL248825 | furan-2-ylmethyl 2-(3,4-dichlorophenyl)cyclopent-1-enecarboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14Cl2O3 |
|---|
| Mol. Mass. | 337.197 |
|---|
| SMILES | Clc1ccc(cc1Cl)C1=C(CCC1)C(=O)OCc1ccco1 |t:9| |
|---|
| Structure | 
|
|---|
Search and Browse
