| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX12 |
|---|
| Ligand | BDBM50222279 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_457824 (CHEMBL924094) |
|---|
| IC50 | 5800±n/a nM |
|---|
| Citation |  Vasquez-Martinez, Y; Ohri, RV; Kenyon, V; Holman, TR; Sepúlveda-Boza, S Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. Bioorg Med Chem15:7408-25 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyunsaturated fatty acid lipoxygenase ALOX12 |
|---|
| Name: | Polyunsaturated fatty acid lipoxygenase ALOX12 |
|---|
| Synonyms: | 12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 75689.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P18054 |
|---|
| Residue: | 663 |
|---|
| Sequence: | MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
|
|
|
|---|
| BDBM50222279 |
|---|
| n/a |
|---|
| Name | BDBM50222279 |
|---|
| Synonyms: | 6,7-dihydroxy-4'-nitroisoflavone | CHEMBL238821 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H9NO7 |
|---|
| Mol. Mass. | 315.2345 |
|---|
| SMILES | Oc1cc2occ(-c3ccc(c(O)c3)[N+]([O-])=O)c(=O)c2cc1O |
|---|
| Structure | 
|
|---|
Search and Browse
