| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase C |
|---|
| Ligand | BDBM50224734 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_450879 (CHEMBL899965) |
|---|
| IC50 | 227±n/a nM |
|---|
| Citation |  Bavetsias, V; Sun, C; Bouloc, N; Reynisson, J; Workman, P; Linardopoulos, S; McDonald, E Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases. Bioorg Med Chem Lett17:6567-71 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase C |
|---|
| Name: | Aurora kinase C |
|---|
| Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35602.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. |
|---|
| Residue: | 309 |
|---|
| Sequence: | MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
|
|
|
|---|
| BDBM50224734 |
|---|
| n/a |
|---|
| Name | BDBM50224734 |
|---|
| Synonyms: | 2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]-pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide | 2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide | CHEMBL392525 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25ClN8OS |
|---|
| Mol. Mass. | 497.016 |
|---|
| SMILES | CN(C)c1ccc(cc1)-c1nc2ncc(Cl)c(N3CCN(CC(=O)Nc4nccs4)CC3)c2[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
