Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Ligand | BDBM50228132 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_452413 (CHEMBL902649) |
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Kd | 1285000±n/a nM |
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Citation | Stebbins, JL; Zhang, Z; Chen, J; Wu, B; Emdadi, A; Williams, ME; Cashman, J; Pellecchia, M Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors. J Med Chem50:6607-17 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
Synonyms: | 12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B |
Type: | Isomerase |
Mol. Mass.: | 11953.09 |
Organism: | Homo sapiens (Human) |
Description: | P62942 |
Residue: | 108 |
Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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BDBM50228132 |
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n/a |
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Name | BDBM50228132 |
Synonyms: | 3-(3-(4-(2-(4-isopropylphenylsulfonyl)acetyl)morpholine-3-carbonyloxy)propyl)pyridine-1-oxide | CHEMBL235114 |
Type | Small organic molecule |
Emp. Form. | C24H30N2O7S |
Mol. Mass. | 490.569 |
SMILES | CC(C)c1ccc(cc1)S(=O)(=O)CC(=O)N1CCOCC1C(=O)OCCCc1ccc[n+]([O-])c1 |w:20.22| |
Structure |
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