Reaction Details |
| Report a problem with these data |
Target | Histone deacetylase 8 |
---|
Ligand | BDBM50229189 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_461762 (CHEMBL927768) |
---|
IC50 | >20000±n/a nM |
---|
Citation | Witter, DJ; Harrington, P; Wilson, KJ; Chenard, M; Fleming, JC; Haines, B; Kral, AM; Secrist, JP; Miller, TA Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2). Bioorg Med Chem Lett18:726-31 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone deacetylase 8 |
---|
Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
|
|
|
BDBM50229189 |
---|
n/a |
---|
Name | BDBM50229189 |
Synonyms: | CHEMBL253868 | US9096559, 2a | [4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester |
Type | Small organic molecule |
Emp. Form. | C27H24N4O3 |
Mol. Mass. | 452.5045 |
SMILES | Nc1ccc(cc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1)-c1ccccc1 |
Structure |
|