| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 3 |
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| Ligand | BDBM50231372 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_461963 (CHEMBL945751) |
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| IC50 | 238±n/a nM |
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| Citation |  Gardner, DS; Santella, JB; Tebben, AJ; Batt, DG; Ko, SS; Traeger, SC; Welch, PK; Wadman, EA; Davies, P; Carter, PH; Duncia, JV From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists. Bioorg Med Chem Lett18:586-95 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 3 |
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| Name: | C-C chemokine receptor type 3 |
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| Synonyms: | C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 41053.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51677 |
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| Residue: | 355 |
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| Sequence: | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
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| BDBM50231372 |
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| n/a |
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| Name | BDBM50231372 |
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| Synonyms: | 1-((2R,3S)-3-hydroxy-4-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)(methyl)amino)butan-2-yl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)urea | CHEMBL252628 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H31N7O3 |
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| Mol. Mass. | 453.5373 |
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| SMILES | C[C@@H](NC(=O)Nc1cccc(c1)-c1nnnn1C)[C@@H](O)CN(C)[C@H](C)[C@@H](O)c1ccccc1 |
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| Structure | 
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