| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
|---|
| Ligand | BDBM50235748 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_462735 (CHEMBL928656) |
|---|
| Ki | 62±n/a nM |
|---|
| Citation |  Tran, JA; Tucci, FC; Arellano, M; Jiang, W; Chen, CW; Marinkovic, D; Fleck, BA; Wen, J; Foster, AC; Chen, C Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands. Bioorg Med Chem Lett18:1931-8 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Melanocortin receptor 4 |
|---|
| Name: | Melanocortin receptor 4 |
|---|
| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36949.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P32245 |
|---|
| Residue: | 332 |
|---|
| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
|
|
|
|---|
| BDBM50235748 |
|---|
| n/a |
|---|
| Name | BDBM50235748 |
|---|
| Synonyms: | 1-((2S,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)piperazine-4-carbonyl)-3-(4-chlorophenyl)pyrrolidin-1-yl)propan-1-one | CHEMBL403699 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H39ClN4O2 |
|---|
| Mol. Mass. | 511.099 |
|---|
| SMILES | CCC(=O)N1CC[C@@H]([C@H]1C(=O)N1CCN(CC1)c1ccc(C)cc1[C@@H](N)C(C)C)c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
