| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 1 |
|---|
| Ligand | BDBM4882 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_563684 (CHEMBL964245) |
|---|
| IC50 | 10000±n/a nM |
|---|
| Citation |  Mohammadi, M; McMahon, G; Sun, L; Tang, C; Hirth, P; Yeh, BK; Hubbard, SR; Schlessinger, J Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science276:955-60 (1997) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fibroblast growth factor receptor 1 |
|---|
| Name: | Fibroblast growth factor receptor 1 |
|---|
| Synonyms: | FGFR1_MOUSE | Fgfr1 | Fibroblast growth factor receptor | Fibroblast growth factor receptor 1 | Flg |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 91976.92 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_306384 |
|---|
| Residue: | 822 |
|---|
| Sequence: | MWGWKCLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDD
VQSINWLRDGVQLVESNRTRITGEEVEVRDSIPADSGLYACVTSSPSGSDTTYFSVNVSD
ALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
ALEERPAVMTSPLYLEIIIYCTGAFLISCMLGSVIIYKMKSGTKKSDFHSQMAVHKLAKS
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD
KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSIPLDQYSPSF
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPTQLANSGLKRR
|
|
|
|---|
| BDBM4882 |
|---|
| n/a |
|---|
| Name | BDBM4882 |
|---|
| Synonyms: | (Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)methylidenyl]indolin-2-one | 3-(4-methyl-2-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid | CHEMBL89363 | KDR Kinase Inhibitor, 5 | SU5402 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H16N2O3 |
|---|
| Mol. Mass. | 296.3205 |
|---|
| SMILES | Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
