| Reaction Details |
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 | Report a problem with these data |
| Target | Growth hormone secretagogue receptor type 1 |
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| Ligand | BDBM50260269 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_509095 (CHEMBL1007239) |
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| IC50 | >1000±n/a nM |
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| Citation |  Holst, B; Mokrosinski, J; Lang, M; Brandt, E; Nygaard, R; Frimurer, TM; Beck-Sickinger, AG; Schwartz, TW Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem282:15799-811 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth hormone secretagogue receptor type 1 |
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| Name: | Growth hormone secretagogue receptor type 1 |
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| Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
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| Type: | Receptor |
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| Mol. Mass.: | 41334.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
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| Residue: | 366 |
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| Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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| BDBM50260269 |
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| n/a |
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| Name | BDBM50260269 |
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| Synonyms: | CHEMBL450217 | wFwLL-NH2 |
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| Type | Small organic molecule |
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| Emp. Form. | C43H54N8O5 |
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| Mol. Mass. | 762.9395 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O |r| |
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| Structure | 
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